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Search Results for " HepG2 cells "

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Others Reactive Oxygen Species Antifungal

125

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天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T5116	Iprodione		Others , Reactive Oxygen Species , Antifungal
	Iprodione is a fungicide. Iprodione is also used in cannabis testing kits as a component of pesticide mixes.		Others , Reactive Oxygen Species , Antifungal
T2496	(Z)-Semaxinib	SU5416	VEGFR
	(Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition for FGFR, InsR, and EGFR. (Z)-Semaxinib is a quinolone derivative w...		VEGFR
T9753	LEI110		Phospholipase
	LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol hydrolases (i.e., PLA2G16, HRASLS2, RARRES3 and iNAT).		Phospholipase
T15371	Gardiquimod		TLR , HIV Protease
	Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells...		TLR , HIV Protease
T27478	GSK3987		Liver X Receptor
	GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.		Liver X Receptor
T1057	Azilsartan	TAK-536	RAAS
	Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pres...		RAAS
T9945	MNK8	3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione	STAT
	MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1].		STAT
T1406	Amantadine hydrochloride	1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride	Dopamine Receptor , Influenza Virus
	Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.		Dopamine Receptor , Influenza Virus
T6412	CVT-12012		Stearoyl-CoA Desaturase (SCD)
	CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).		Stearoyl-CoA Desaturase (SCD)
T14766	BPH-715		Others , Parasite
	BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth. With an IC50 of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells[1].		Others , Parasite
T28903	T-3364366	T 3364366,T3364366	Others
	T-3364366 is an inhibitor of thienopyrimidinone delta-5 desaturase (Δ5D) with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively.		Others
T12931	SLC13A5-IN-1		Stearoyl-CoA Desaturase (SCD)
			Stearoyl-CoA Desaturase (SCD)
T65086	Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride		Apoptosis , Phosphatase
	Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride may cause sensitization. Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride promotes apoptosis in HepG2 (IC50= 62 μM) and SK-Hep1 (IC50= 151 μM) cells and inhibits protein pho...		Apoptosis , Phosphatase
TP1881L1	Pep 2-8 ammonium salt(1541011-97-5 free base)		Others
	Pep 2-8 ammonium salt is Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.		Others
T3132	SC66		Apoptosis , Akt
	SC66 is a AKT inhibitor in HepG2, HA22T/VGH, and PLC/PRF/5 cells (IC50: about 0.75 μg/ml, at 72 h).		Apoptosis , Akt
T7088	Diflubenzuron	Dimilin,Difubenzuron,Larvakil,Difluron	P450
	Diflubenzuron (Larvakil) is a benzoyl-urea insecticide, found to be a potent inhibitor of melanosome synthesis in mouse melanoma cells. Diflubenzuron has also been shown to inhibit TCDD-induced CYP1A1 expression in HepG2...		P450
T83627	Pim-1 kinase inhibitor 8		Pim , PKC
	Pim-1 kinase inhibitor 8 is a potent Pim-1 kinase inhibitor with anticancer activity and can effectively inhibit cell migration.Pim-1 kinase inhibitor 8 is cytotoxic to MCF-7 and HepG2 cells, and is a candidate compound ...		Pim , PKC
T60654	KDM4C-IN-1		Histone Demethylase
	KDM4C-IN-1 is a selective and potent KDM4C inhibitor (IC50: 8 nM) with potential anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia.		Histone Demethylase
T67776	PCSK9-IN-11		Others
	PCSK9-IN-11 (compound 5r) is a potent PCSK9 inhibitor with oral activity. PCSK9-IN-11 shows inhibitory activity of PCSK9 transcription in HepG2 cells (IC50= 5.7 μM). PCSK9-IN-11 can increase LDL receptor (LDLR) protein l...		Others
T67791	BMS-903452		GPR
	BMS-903452 is a potent and selective GPR119 agonist with EC50 of 14 nM. BMS-903452 is indicated for the treatment of acute and chronic rodent diabetes. GPR119 was mainly expressed in pancreatic b cells and gastrointestin...		GPR
T8740	COH-SR4	COH-SR4 (Mitochondria uncoupler SR4)	Others , AMPK
	COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation. COH-SR4 modulates amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inhibiting proli...		Others , AMPK
T14878	CAY10566		Dehydrogenase , Stearoyl-CoA Desaturase (SCD)
	CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally ...		Dehydrogenase , Stearoyl-CoA Desaturase (SCD)
T37149	Carbamazepine 10,11-epoxide		Others
	Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.1,2It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells e...		Others
T36126	TMP-153
	Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and choleste...
T0085L	Entecavir	BMS200475,SQ34676	HBV
	Entecavir (SQ34676) is a guanosine nucleoside analogue used in the treatment of chronic hepatitis B virus (HBV) infection. Entecavir therapy can be associated with flares of the underlying hepatitis B during or after the...		HBV
T0085	Entecavir monohydrate	SQ 34676,BMS-200475,Entecavir hydrate	HBV
	Entecavir monohydrate (BMS-200475) is a selective inhibitor of the replication of the hepatitis B virus (HBV). It, a new deoxyguanine nucleoside analog.		HBV
T26863	BMS-929075	BMS 929075,BMS929075	HCV Protease
	BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic parameters.BMS-929075 shows cytotoxicity.		HCV Protease
T73582	EB1		MNK
	EB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 μM and 9.4 μM, respectively.EB1 inhibits the growth of cancer cells, promotes apoptosis, and inhibits t...		MNK
T72057	H1k		CDK
	H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyc...		CDK
T15675	Tirbanibulin Mesylate	KX2-391 Mesylate,KX01 Mesylate	Microtubule Associated , Src
	Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).		Microtubule Associated , Src
T20907	DBC	3,4,5,6-Dibenzocarbazole
	DBC, a ubiquitous environmental pollutant, induces significant DNA strand break levels and micronuclei in HepG2 cells.
T34582	SC-III3
	SC-III3 is a novel scopoletin derivative, induces autophagy of human hepatoma HepG2 cells through AMPK/mTOR signaling pathway by acting on mitochondria. SC-III3 reduces the viability of HepG2 cells and tumor growth of He...
T61202	TDO-IN-1		Others
	TDO-IN-1 is an orally active, potent, and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which inhibits indoleamine-2,3-dioxygenase.TDO-IN-1 has antitumor activity and is able to act by reversing local immune t...		Others
T26936	C188	Cpd188,STAT3-IN-C188,Cpd-188,C 188,C-188
	C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, ...
T34492	Salinazid	Nilazid,Salicylaldehyde isonicotinoyl hydrazone,Salizid,Salizide,Nupasal,SIH1	Others
	Salinazid (Salicylaldehyde isonicotinoyl hydrazone) is a potent Cu(II) ionophore which preferentially kills HepG2 cells over HUVEC cells, and is superior to clioquinol.		Others
T60460	Tubulin inhibitor 16
	Tubulin inhibitor 16 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 16 exhibits cytotoxicity in HepG2 cells [1].
T60459	Tubulin inhibitor 15
	Tubulin inhibitor 15 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 15 exhibits cytotoxicity in HepG2 cells [1].
T37544	Anhydroophiobolin A
	Anhydroophiobolin A is an ophiobolin fungal metabolite that has been found in C. heterostrophus fermentation broths. It is cytotoxic to HepG2 and K562 cancer cells (IC50s = 55.7 and 39.5 μM, respectively).
T63671	Anticancer agent 60
	Anticancer agent 60 showed anti-proliferative effect on human HepG2 cells with an IC50 value of 4.13 μM. Anticancer agent 60 exhibited anti-tumor activity in a human HepG2 xenograft mouse model.
T31083	CP-868388 free base	CP868388,CP 868388,(-)-CP-868388,UNII-999KY5ZIGB,CP-868388	PPAR
	CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslipidemia.		PPAR
T37007	Resistoflavine
	Resistoflavine is a metabolite of the marine actinomycete S. chibaensis. It slows the growth of and is cytotoxic to HMO2 and HepG2 cells with mean lethal concentrations (LC50) of 0.013 and 0.016 μg/ml, respectively.
T39048	Sel-green
	Sel-green is a selective selenol fluorescent probe used for quantifying the selenocysteine (Sec) content in the selenoenzyme thioredoxin reductase, as well as imaging endogenous Sec in live HepG2 cells.
T71815	TX-1918
	TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K). TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells.
T83050	Anti-inflammatory agent 62
	Anti-inflammatory agent 62 mitigates acetaminophen-induced hepatotoxicity in HepG2 cells by modulating inflammatory and oxidative stress pathways [1].
T72844	EGFR/CDK2-IN-1
	EGFR/CDK2-IN-1, an inhibitor of both EGFR and CDK2, demonstrates effective cytotoxicity towards MCF7 and HepG2 cells, suggesting its potential application in cancer research.
T22560	ALK5 Inhibitor II (hydrochloride)		Others
	ALK5 Inhibitor II is an ALK5 inhibitor. IC50: 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively.		Others
T61461	Anticancer agent 37
	Anticancer agent 37 (compound 18) is a sulfonylurea derivative known for its potent anticancer activity. It efficiently inhibits the growth of HePG2 cells, displaying an IC 50 value of 17.2 μg/mL [1].
T38775	LeuRS-IN-1
	LeuRS-IN-1 is a highly potent and orally active inhibitor of the leucyl-tRNA synthetase enzyme derived from Mycobacterium tuberculosis (M.tb LeuRS). It exhibits significant inhibitory activity against M.tb LeuRS with IC ...
T83051	Anti-inflammatory agent 61
	Compound 5b (Anti-inflammatory agent 61) is a potent anti-inflammatory agent that diminishes TNF-α expression in LPS-induced inflammation within RAW 264.7 cells and mitigates APAP-induced inflammation in HepG2 cells [1].
T72487	Anticancer agent 99
	Anticancer agent 99 exhibits potent anticancer activity towards HepG2 cells, evidenced by an IC50 value of 35.9 μM. It effectively induces apoptosis and inhibits cell proliferation.

Compounds

Iprodione

T5116

Synonym:

Target: Others, Reactive Oxygen Species, Antifungal

Target: Phospholipase

Gardiquimod

T15371

Synonym:

Target: TLR, HIV Protease

GSK3987

T27478

Synonym:

Target: Liver X Receptor

Synonym: 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione

Target: STAT

Amantadine hydrochloride

T1406

Synonym: 1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride

Target: Dopamine Receptor, Influenza Virus

CVT-12012

T6412

Synonym:

Target: Stearoyl-CoA Desaturase (SCD)

BPH-715

T14766

Synonym:

Target: Others, Parasite

T-3364366

T28903

Synonym: T 3364366,T3364366

Target: Stearoyl-CoA Desaturase (SCD)

Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride

T65086

Synonym:

Target: Apoptosis, Phosphatase

Pep 2-8 ammonium salt(1541011-97-5 free base)

Target: Apoptosis, Akt

Diflubenzuron

T7088

Synonym: Dimilin,Difubenzuron,Larvakil,Difluron

Target: P450

Pim-1 kinase inhibitor 8

Target: Histone Demethylase

Synonym: COH-SR4 (Mitochondria uncoupler SR4)

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Carbamazepine 10,11-epoxide

Synonym: BMS200475,SQ34676

Target: HBV

Entecavir monohydrate

T0085

Synonym: SQ 34676,BMS-200475,Entecavir hydrate

Target: HBV

BMS-929075

T26863

Synonym: BMS 929075,BMS929075

Tirbanibulin Mesylate

T15675

Synonym: KX2-391 Mesylate,KX01 Mesylate

Target: Microtubule Associated, Src

DBC

T20907

Synonym: 3,4,5,6-Dibenzocarbazole

Synonym: Cpd188,STAT3-IN-C188,Cpd-188,C 188,C-188

Target:

Salinazid

T34492

Synonym: Nilazid,Salicylaldehyde isonicotinoyl hydrazone,Salizid,Salizide,Nupasal,SIH1

Synonym: CP868388,CP 868388,(-)-CP-868388,UNII-999KY5ZIGB,CP-868388

Anti-inflammatory agent 62

ALK5 Inhibitor II (hydrochloride)

Anti-inflammatory agent 61

カタログ番号	製品名	別名	ターゲット
T3S1251	Neoruscogenin		ROR
	1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.		ROR
T4034	Solamargine	Solamargin,δ-Solanigrine	Apoptosis , p38 MAPK , P-gp , STAT
	Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cel...		Apoptosis , p38 MAPK , P-gp , STAT
T3673	Mollugin	Rubimaillin	HER , JAK
	Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upr...		HER , JAK
T7060	Amantadine	1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine	Others
	Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.		Others
T3844	Deltonin		ERK , Others , Akt , Endogenous Metabolite
	Deltonin has an inhibition of ERK1/2 and AKT activation. Deltonin shows cytotoxicity against human HepG2 cells (IC50: 7.66 μM), mouse C26 cells (IC50: 1.22 μM), and human MDA-MB-231 cells (IC50: 1.58 μM).		ERK , Others , Akt , Endogenous Metabolite
T5A2455	Arenobufagin		Others
	Arenobufagin is a natural bufadienolide from toad venom with potent antineoplastic activity against HCC HepG2 cells and corresponding multidrug-resistant HepG2/ADM cells.		Others
TN2100	Pratensein		Others , NF-κB
	Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.		Others , NF-κB
TN1058	Pelargonidin chloride		NOS , Reactive Oxygen Species , Nrf2 , NO Synthase
	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 signaling pathway.		NOS , Reactive Oxygen Species , Nrf2 , NO Synthase
TN1644	Flavanomarein		Others
	Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells trea...		Others
T4519	Alisol A	Alisol-A	Autophagy
	Alisol A (Alisol-A) may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cells).		Autophagy
T5S1331	Herbacetin		c-Met/HGFR , Akt
	1. Herbacetin induces apoptosis in HepG2 cells, by ROS and PI3K/Akt pathway. 2. Herbacetin suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation.		c-Met/HGFR , Akt
T3S2325	Ardisiacrispin A	Saxifragifolin B,LTS-4,Deglucocyclamin	HSV
	Ardisiacrispin A (Deglucocyclamin) has cytotoxic activity toward HepG2 cancer cell with the GI(50) value of 1.56μM, it could inhibit the proliferation of Bel-7402 cells by inducing apoptosis and disassembling microtubule...		HSV
T3904	Gomisin J		Calcium Channel , AMPK
	Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK...		Calcium Channel , AMPK
T7027	EURYCOMANONE	Pasakbumin A	Others
	Eurycomanone (Pasakbumin A) is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.Eurycomanone has anti-cancer activity, inhibits A549 lung cancer cell p...		Others
TN6694	5,6-Benzoflavone	β-Naphthoflavone,beta-NF	Antioxidant
	5,6-Benzoflavone (β-Naphthoflavone) is an exogenous ligand for the aryl hydrocarbon receptor, which disrupts zinc homeostasis in human hepatocellular carcinoma HepG2 cells. 5,6-Benzoflavone (β-Naphthoflavone) possesses a...		Antioxidant
TN2244	Sulfuretin		NF-κB , Autophagy
	Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 thr...		NF-κB , Autophagy
T3867	Alpinetin	(-)-alpinetin	BCL , PPAR
	Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeutic agent CDDP. Alpinetin has strong anti-he...		BCL , PPAR
T2854	Phillyrin	Forsythin	P450 , Influenza Virus , AMPK
	Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activ...		P450 , Influenza Virus , AMPK
TN2111	Prunin	Naringenin 7-0-glucoside	Phosphatase , Anti-infection , Virus Protease
	Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can...		Phosphatase , Anti-infection , Virus Protease
T6S2023	Harpagoside		Others , COX , NO Synthase
	1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit lipopolysaccharide-induced mRNA levels and protein expression...		Others , COX , NO Synthase
TL0008	Gigantol		Wnt/beta-catenin , Glucosidase
	Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a...		Wnt/beta-catenin , Glucosidase
TN1856	Leachianone A	Isokurarinone	SGLT
	Leachianone A (Isokurarinone) is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.		SGLT
T6S1141	Ganoderic acid A		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
	1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis a...		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
T3895	Polyphyllin I		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha...		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
TN1163	2'-Hydroxychalcone		Others
	2'-Hydroxychalcone is a drug synthesis intermediate for the synthesis of flavonoids. 2'-Hydroxychalcone loaded in nanoemulsion showed fungicidal activity against Coccidioides parapsilosis in Danio rerio model.2'-Hydroxyc...		Others
T4S1637	Gamma-Mangostin	Normangostin	Others , 5-HT Receptor
	1. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin ...		Others , 5-HT Receptor
TN1393	(-)-Anonaine		Apoptosis , Antioxidant , Parasite , Antifungal
	(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces ...		Apoptosis , Antioxidant , Parasite , Antifungal
T4S0145	Corylifol A	Corylinin	hCE , STAT , UGT
	1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potentia...		hCE , STAT , UGT
T1704	Diosmetin	Luteolin 4-methyl ether	P450 , Trk receptor
	Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist.		P450 , Trk receptor
T3S1416	Decursin	Decursinol angelate,(+)-Decursin	Apoptosis , PKC
	1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , potentially by inhibiting the TGF-β1 ...		Apoptosis , PKC
T3776	Rhapontigenin	Protigenin	P450 , Antibacterial , Antifungal
	Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. R...		P450 , Antibacterial , Antifungal
TN5346	Psiguadial D
	Psiguadial D shows significant cytotoxicity toward HepG2 and HepG2/ADM cells.
T10045	15-Acetyl-deoxynivalenol		Others
	15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals and exhibits toxicity to HepG2 cells.		Others
T81521	Penispidin A
	Penispidin A suppresses lipid accumulation in hepatic HepG2 cells.
T28021	Meso-Dihydroguaiaretic acid
	meso-Dihydroguaiaretic acid is an LXR-α antagonist, it inhibits hepatic lipid accumulation by activating AMP-activated protein kinase in human HepG2 cells.
TN3630	Chartarlactam A		Others
	Chartarlactam A shows antihyperlipidemic effects in HepG2 cells.		Others
T81531	Pedunculosumoside F
	Pedunculosumoside F, a homoflavonoid glucoside extracted from Ophioglossum pedunculosum, exhibits cytotoxicity against HepG2 22.15 cells, presenting a CC50 value of 56.7 μM, yet lacks anti-HBV activity. Conversely, its a...
TN4513	Meliasenin B		Others
	Meliasenin B may cause hepatotoxicity, it displays dose-dependent toxicity on HepG2 cells.		Others
T39613	11-epi-mogroside V
	11-epi-mogroside V, a compound found in the fruit of Siraitia grosvenori, possesses significant bioactivity by enhancing glucose uptake in vitro, specifically in human HepG2 cells.
TN4890	Rabdosin B		Others
	Rabdosin B shows cytotoxic activity against three human tumour HepG2, GLC-82 and HL-60 cell lines, it induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner. Rabdosin B at higher concentration...		Others
TN3012	4,5-Dihydroblumenol A		HBV
	4, 5-Dihydroblumenol shows significant inhibition against HepG2 cells transected with cloned hepatitis B virus DNA.		HBV
TN3511	Bi-linderone		Others
	Bi-linderone shows significant activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 microg/mL.		Others
TN3688	Coelonin		Others
	Coelonin shows moderate cytotoxic activity against HepG2 cells.		Others
T5526	Glycoborinine		BCL , PARP , ROS , Caspase
	Glycoborinine is a potential molecule against cancer cells, it can induce HepG2 apoptosis through the mitochondrial-dependent pathway. Glycoborinine has photo-activated antimicrobial activity, it shows moderate inhibitio...		BCL , PARP , ROS , Caspase
TN4266	Isobonducellin		Antifection
	Isobonducellin exhibits potent cytotoxic activity in Jurkat and HepG2 cells, while moderate growth inhibition against Colon205 cells.		Antifection
TN1670	Ganodermanondiol		HIV Protease , Nrf2 , AMPK
	Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.		HIV Protease , Nrf2 , AMPK
TN6645	Lucidumol A
	Lucidumol A has relatively good effect against aldose reductase with IC50 of 19.1uM. Lucidumol A has cytotoxic activity, it reduced cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependen...
T13629	Cyclo(Ala-Gly)		Others
	Cyclo (Ala-Gly) is a mangrove endophytic fungus, a metabolite of Penicillium thomi, which is cytotoxic to A549, HepG2 and HT29 cells. The IC50 value is in the range of 9.5-18.1 μM.		Others
T40440	Isobyakangelicol	Isobyakangelicol,Anhydrobyakangelicin
	Isobyakangelicol, a coumarin compound present in Angelica dahurica roots, exhibits inhibitory effects on the growth of HeLa and HepG2 cells, with IC50 values of 70.04 μM and 17.97 μM, respectively.
TN1903	Magnolignan A		Others
	Magnolignan A-2-O-beta-D-glucopyranoside has medium cytotoxic activity against HEp-2 and HepG2 cells, with IC(50) of 13.3 microM, and 46.4 microM, respectively.		Others
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天然物製品

Synonym: Solamargin,δ-Solanigrine

Target: Apoptosis, p38 MAPK, P-gp, STAT

Synonym: 1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine

Target: ERK, Others, Akt, Endogenous Metabolite

Target: Others, NF-κB

Pelargonidin chloride

TN1058

Synonym:

Target: NOS, Reactive Oxygen Species, Nrf2, NO Synthase

Target: c-Met/HGFR, Akt

Ardisiacrispin A

T3S2325

Synonym: Saxifragifolin B,LTS-4,Deglucocyclamin

Target: Calcium Channel, AMPK

EURYCOMANONE

T7027

Synonym: Pasakbumin A

Target: Others

5,6-Benzoflavone

TN6694

Synonym: β-Naphthoflavone,beta-NF

Target: NF-κB, Autophagy

Alpinetin

T3867

Synonym: (-)-alpinetin

Target: P450, Influenza Virus, AMPK

Prunin

TN2111

Synonym: Naringenin 7-0-glucoside

Target: Phosphatase, Anti-infection, Virus Protease

Harpagoside

T6S2023

Synonym:

Target: Others, COX, NO Synthase

Gigantol

TL0008

Synonym:

Target: Wnt/beta-catenin, Glucosidase

Leachianone A

TN1856

Synonym: Isokurarinone

Target: Apoptosis, NF-κB, Endogenous Metabolite, Autophagy

Polyphyllin I

T3895

Synonym:

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

Synonym: Normangostin

Target: Others, 5-HT Receptor

(-)-Anonaine

TN1393

Synonym:

Target: Apoptosis, Antioxidant, Parasite, Antifungal

Corylifol A

T4S0145

Synonym: Corylinin

Target: hCE, STAT, UGT

Diosmetin

T1704

Synonym: Luteolin 4-methyl ether

Target: P450, Trk receptor

Decursin

T3S1416

Synonym: Decursinol angelate,(+)-Decursin

Target: Apoptosis, PKC

Rhapontigenin

T3776

Synonym: Protigenin

Target: P450, Antibacterial, Antifungal

15-Acetyl-deoxynivalenol

meso-Dihydroguaiaretic acid

4,5-Dihydroblumenol A

Target: BCL, PARP, ROS, Caspase

Target: HIV Protease, Nrf2, AMPK

Synonym: Isobyakangelicol,Anhydrobyakangelicin

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00386	GLT8D2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	GLT8D2 is a glycosyltransferase of apoB100 that regulates apoB100 levels in hepatocytes. GLT8D2 expression increased in steatosis HepG2 cells compared with that in normal HepG2 cells. GLT8D2 participated in nonalcoholic ...
TMPJ-01142	CDO1 Protein, Human, Recombinant (His)	Human	E. coli
	Cysteine Dioxygenase Type 1 (CDO1) is a mammalian non-heme iron enzyme that belongs to the cysteine dioxygenase family. CDO1 is highly expressed in the liver and placenta, and has a low expression in heart, brain and pan...
TMPY-01595	PCBP1 Protein, Human, Recombinant (His)	Human	E. coli
	Poly(rC)-binding protein 1, also known as Heterogeneous nuclear ribonucleoprotein E1, Alpha-CP1, Nucleic acid-binding protein SUB2.3 and PCBP1, is a family member of heterogeneous nuclear ribonucleoproteins (hnRNPs) that...

GLT8D2 Protein, Human, Recombinant (His)

TMPY-00386

Species: Human

Expression System: Baculovirus-Insect Cells

CDO1 Protein, Human, Recombinant (His)

TMPJ-01142

Species: Human

Expression System: E. coli

PCBP1 Protein, Human, Recombinant (His)

TMPY-01595

Species: Human

Expression System: E. coli